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Cette section regroupe les recherches en Chimie menées dans le cadre du projet. Vous y trouverez principalement les recherches des équipes du DCM concernant la tyrosinase.
Thèses
Yi Min Ng, Base structurelle des enzymes mélanogènes humaines, Biologie structurale et nanobiologie, ESRF, 2024
Clarisse Faure, Modulation de la biosynthèse de pigments : conception, synthèses et mécanismes d’actions de modulateurs de la tyrosinase, Chimie, DCM (équipes CIRE & SITH), 2021
Articles
E. Buitrago , C. Faure, M. Carotti, E. Bergantino, R. Hardré, M. Maresca, C. Philouze, N. Vanthuyne, A. Boumendjel, L. Bubacco, A. du Moulinet d'Hardemare, H. Jamet, M. Réglier, C. Belle, Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase, Eur J Med Chem. 2023
Clarisse Faure, Amaury du Moulinet d’Hardemare, Hélène Jamet, Catherine Belle, Elisabetta Bergantino, Luigi Bubacco, Maurizio Benfatto, A. Jalila Simaan, Marius Réglier, Transition State Analogue Molecules as Mechanistic Tools and Inhibitors for Tyrosinase, Copper Bioinorganic Chemistry, 2023, pp. 45-80
F. Ricci, K. Schira, L. Khettabi, L. Lombardo, S. Mirabile, R. Gitto, M. Soler-Lopez, J. Scheuermann, G. Wolber, L. De Luca, Computational methods to analyze and predict the binding mode of inhibitors targeting both human and mushroom tyrosinase, Eur J Med Chem, 2023
Clarisse Faure, Yi Ming Ng, Catherine Belle, Montserrat Soler-Lopez, Lyna Khettabi, Melissa Saidi, Nathalie Berthet, Marc Maresca, Christian Philouze, Walid Rachidi, Marius Reglier, Amaury du Moulinet d'Hardemare, Hélène Jamet, Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical studies, Chembiochem, Volume25, Issue12, 2024
Hélène Jamet, Marius Réglier, Catherine Belle, Approche bioinorganique pour comprendre l’activité de la tyrosinase humaine, Actualité Chimique, 499, 52, 2024
M. Catalano, G. Bassi, G. Rotondi, L. Khettabi, M. Dichiara, P. Murer, J. Scheuermann, M. Soler-Lopez, D. Neri, Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein, RSC Med. Chem., 2021,12, pp. 363-369
E. Buitrago, C. Faure, L. Challali, E. Bergantino, A. Boumendjel, L. Bubacco, M. Carotti, R. Hardré, M. Maresca, C. Philouze, H. Jamet, M. Réglier, C. Belle, Ditopic Chelators of Dicopper Centers for Enhanced Tyrosinases Inhibition, Volume27, Chemistry A European Journal, Issue13, 2021, pp. 4384-4393
C. Faure, Dr. H. Jamet, C. Belle, A. du Moulinet d'Hardemare, Exploring Coumarins Reduction: NaBH4/MeOH versus Nickel Boride Generated In Situ, ChemistrySelect, Volume5, Issue46, December 11, 2020, pp. 14735-14740
A. Bijelic, A. Rompel, C. Belle, Tyrosinases: Enzymes, Models and Related Applications, Series on Chemistry, Energy and the Environment Bioinspired Chemistry, 2019, pp. 155-183
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