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Chimie et Biologie

Cette section regroupe les recherches en Chimie menées dans le cadre du projet. Vous y trouverez principalement les recherches des équipes du DCM concernant la tyrosinase.

Crissa structure moleculaire Pixabay

E. Buitrago , C. Faure, M. Carotti, E. Bergantino, R. Hardré, M. Maresca, C. Philouze, N. Vanthuyne, A. Boumendjel, L. Bubacco, A. du Moulinet d'Hardemare, H. Jamet, M. Réglier, C. Belle, Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase, Eur J Med Chem. 2023

Clarisse Faure, Amaury du Moulinet d’Hardemare, Hélène Jamet, Catherine Belle, Elisabetta Bergantino, Luigi Bubacco, Maurizio Benfatto, A. Jalila Simaan, Marius Réglier, Transition State Analogue Molecules as Mechanistic Tools and Inhibitors for Tyrosinase, Copper Bioinorganic Chemistry, 2023, pp. 45-80 

F. Ricci, K. Schira, L. Khettabi, L. Lombardo, S. Mirabile, R. Gitto, M. Soler-Lopez, J. Scheuermann, G. Wolber, L. De Luca, Computational methods to analyze and predict the binding mode of inhibitors targeting both human and mushroom tyrosinase, Eur J Med Chem, 2023

Clarisse Faure, Yi Ming Ng, Catherine Belle, Montserrat Soler-Lopez, Lyna Khettabi, Melissa Saidi, Nathalie Berthet, Marc Maresca, Christian Philouze, Walid Rachidi, Marius Reglier, Amaury du Moulinet d'Hardemare, Hélène Jamet, Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical studies, Chembiochem, Volume25, Issue12, 2024

Hélène Jamet, Marius Réglier, Catherine Belle, Approche bioinorganique pour comprendre l’activité de la tyrosinase humaine, Actualité Chimique, 499, 52, 2024

M. Catalano, G. Bassi, G. Rotondi, L. Khettabi, M. Dichiara, P. Murer, J. Scheuermann, M. Soler-Lopez, D. Neri, Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein, RSC Med. Chem., 2021,12, pp. 363-369

E. Buitrago, C. Faure, L. Challali, E. Bergantino, A. Boumendjel, L. Bubacco, M. Carotti, R. Hardré, M. Maresca, C. Philouze, H. Jamet, M. Réglier, C. Belle, Ditopic Chelators of Dicopper Centers for Enhanced Tyrosinases Inhibition, Volume27, Chemistry A European Journal, Issue13, 2021, pp. 4384-4393

C. Faure, Dr. H. Jamet, C. Belle, A. du Moulinet d'Hardemare, Exploring Coumarins Reduction: NaBH4/MeOH versus Nickel Boride Generated In Situ, ChemistrySelect, Volume5, Issue46, December 11, 2020, pp. 14735-14740

A. Bijelic, A. Rompel, C. Belle, Tyrosinases: Enzymes, Models and Related Applications, Series on Chemistry, Energy and the Environment Bioinspired Chemistry, 2019, pp. 155-183 

 

Publié le 24 mars 2025

Mis à jour le 9 mai 2025